This project empowers the broader chemistry community with access to grid computing. The team proposing this work includes both technologists who have long been involved in the activities of high-end computing, grid infrastructure, collaboration tools, and other technologies - precursors of the emerging cyberinfrastructure - and chemistry researchers specializing in the use of computational tools to further their research goals. This project will not only support advances in chemistry but will be a leading example for deploying such capabilities to other scientific and engineering research communities. Further, these capabilities have enormous potential impact to those industries which generate new materials so important to the electronic, biotechnology and medical sectors. One has only to think of the development of nanotechnology devices and pharmaceuticals to realize how important computational chemistry is to the country's economy and the availability of integrated technologies to support their development.